C - Chemistry – Metallurgy – 12 – Q
Patent
C - Chemistry, Metallurgy
12
Q
C12Q 1/68 (2006.01) C07K 14/575 (2006.01) C12N 15/10 (2006.01) C12P 19/34 (2006.01) G01N 33/53 (2006.01) G01N 33/566 (2006.01) A61K 38/00 (2006.01)
Patent
CA 2324510
The present invention relates to the mammalian PACAP gene. The invention relates to methods for the identification of compounds that modulates the expression of PACAP and to using such compounds as therapeutics agents in the treatment of PACAP disorders. The invention also relates to methods for the diagnostic evaluation, genetic testing and prognosis of PACAP mediated disorders, and to methods and compositions for the treatment of these disorders. The invention also relates to use of the PACAP gene and/or gene products as markers for fine structure mapping of a region of human chromosome 18, including a region of the chromosome involved in mediating neuropsychiatric disorders.
L'invention concerne le gène mammifère PACAP. Elle concerne des procédés servant à identifier des composés modulant l'expression de PACAP, ainsi que l'utilisation de ces composés en tant qu'agents thérapeutiques servant à traiter des maladies provoquées par PACAP. Elle concerne également des procédés servant à effectuer une évaluation diagnostique, des essais génétiques et le pronostic de maladies provoquées par PACAP, des procédés et des compositions servant à traiter ces maladies. Elle concerne, de plus, l'utilisation du gène PACAP et/ou de ses produits de recombinaison en tant que marqueurs afin d'établir la cartographie précise de la structure d'une zone du chromosome humain 18, y compris une zone de ce chromosome jouant un rôle médiateur dans l'apparition de maladies neuropsychiatriques.
Chen Hong
Freimer Nelson B.
Millennium Pharmaceuticals Inc.
Osler Hoskin & Harcourt Llp
The Regents Of The University Of California
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