C - Chemistry – Metallurgy – 12 – Q
Patent
C - Chemistry, Metallurgy
12
Q
C12Q 1/68 (2006.01) C07H 21/04 (2006.01) C07K 5/00 (2006.01) C07K 14/00 (2006.01) C07K 16/00 (2006.01) C12N 15/63 (2006.01) C12N 15/85 (2006.01) C12N 15/86 (2006.01) G01N 33/68 (2006.01)
Patent
CA 2327652
The present invention relates to the mammalian Hcen-2 gene. The invention relates to methods for the identification of compounds that modulate the expression of Hcen-2 and to using such compounds as therapeutic agents in the treatment of Hcen-2 disorders. The invention also relates to methods for the diagnostic evaluation, genetic testing and prognosis of Hcen-2 mediated disorders, and to methods and compositions for the treatment of these disorders. The invention also relates to use of the Hcen-2 gene and/or gene products as markers for fine structure mapping of a region of human chromosome 18, including a region of the chromosome involved in mediating neuropsychiatric disorders.
L'invention se rapporte au gène mammalien Hcen-2 et concerne des procédés pour identifier les composés qui modulent l'expression de Hcen-2 ainsi que l'utilisation des ces procédés en tant qu'agents thérapeutiques dans le traitement des troubles de Hcen-2. L'invention concerne également des procédés d'évaluation diagnostique, d'examen génétique et de prévision en rapport avec les troubles induits par Hcen-2 ainsi que des procédés et des compositions destinées à traiter ces troubles. L'invention se rapporte également à l'utilisation du gène Hcen-2 et/ou de produits géniques en tant que marqueurs destinés au mappage structurel fin d'une région du chromosome humain 18, y compris une région du chromosome participant à la médiation de troubles neuropsychiatriques.
Chen Hong
Freimer Nelson B.
Millennium Pharmaceuticals Inc.
Osler Hoskin & Harcourt Llp
The Regents Of The University Of California
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