C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
C12N 15/12 (2006.01) C07H 21/00 (2006.01) C07H 21/02 (2006.01) C07H 21/04 (2006.01) C07K 1/00 (2006.01) C07K 14/47 (2006.01) C07K 16/00 (2006.01) C12N 1/14 (2006.01) C12N 1/20 (2006.01) C12N 15/00 (2006.01) C12P 21/04 (2006.01) C12P 21/06 (2006.01) C12Q 1/68 (2006.01) G01N 33/53 (2006.01) A61K 38/00 (2006.01)
Patent
CA 2285017
The present invention relates to the mammalian fsh22 gene, a novel gene associated with bipolar affective disorder (BAD) in humans. The invention encompasses fsh22 nucleic acids, recombinant DNA molecules, cloned genes or degenerate variants thereof, fsh22 gene products and antibodies directed against such gene products, cloning vectors containing mammalian fsh22 gene molecules, and hosts that have been genetically engineered to express such molecules. The invention further relates to methods for the identification of compounds that modulate the expression of fsh22 and to using such compounds as therapeutic agents in the treatment of fsh22 disorders and neuropsychiatric disorders. The invention also relates to methods for the diagnostic evaluation, genetic testing and prognosis of fsh22 disorders and neuropsychiatric disorders including schizophrenia, attention deficit disorder, a schizoaffective disorder, a bipolar affective disorder or a unipolar affective disorder, and to methods and compositions for the treatment of these disorders.
La présente invention porte sur le gène mammalien fsh22, nouveau gène associé à la maladie affective bipolaire (BAD) chez l'homme. Cette invention concerne également des acides nucléiques du gène fsh22, des molécules d'ADN recombiné, des gènes clonés ou leurs variantes dégénérées, des produits géniques de fsh22 et des anticorps dirigés contre ces produits géniques, le clonage de vecteurs contenant les molécules du gène mammalien fsh22, et les hôtes qui sont issus du génie génétique pour exprimer ces molécules. Cette invention se rapporte encore à des procédés d'identification des composés qui modulent l'expression de fsh22 et à leur utilisation comme agents thérapeutiques dans le traitement des maladies et troubles dus au gène fsh22; ainsi qu'à des procédés d'évaluation diagnostique, de test génétique et de pronostic des maladies et troubles neuropsychiatriques dus à fsh22 tels que la schizophrénie, les troubles déficitaires de l'attention, les maladies schizophréniques ou les maladies affectives bipolaires, et enfin à des procédés et compositions utilisés dans le traitement de ces pathologies.
Chen Hong
Freimer Nelson B.
Millennium Pharmaceuticals Inc.
Osler Hoskin & Harcourt Llp
The Regents Of The University Of California
LandOfFree
Methods and compositions for the diagnosis and treatment of... does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Methods and compositions for the diagnosis and treatment of..., we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Methods and compositions for the diagnosis and treatment of... will most certainly appreciate the feedback.
Profile ID: LFCA-PAI-O-1580360