Methods and compositions for the direct concentrated...

Details Methods and compositions for the direct concentrated... Methods and compositions for the direct concentrated...

A - Human Necessities

61

K

A61K 39/395 (2006.01) A61K 39/44 (2006.01) A61L 27/00 (2006.01) C07K 16/12 (2006.01) A61K 38/00 (2006.01)

Patent

CA 2153661

Compositions containing a high concentration of the full repertoire of immunoglobulins including IgA, IgM and IgG, are used to combat infections from microorganisms and viruses at a wound, surgical, or burn site, or normal tissue at times of risk of infection. The compositions can contain elevated antibody titers for several specific pathogens including S. aureus, CNS, Enterococci, S. epidemidis, P. aaeruginosa, E. coli, and Enterobacter spp., etc. The composition are applied directly to a wound or burn site as an ointment, creme, fluid, spray, or the like, prior to viral or bacterial attachment or biofilm formation such that adhesion of the pathogens is inhibited and the pathogens closest to the wound or burn site will be pre-opsonized for phagocytic killing prior to toxin release. The immunoglobulins in the composition can be immobilized on a biocompatible material such as collagen, fibrin, hyaluronan, biodegradable polymers, and fragments thereof, which will be placed in-situ at the wound, surgical or burn site. In addition, the immunoglobulins in the composition may be coated on the body containing surface of an implantable device such as a catheter, contact lens or total joint. The inventive compositions have particular application in preventing infections.

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