A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 38/21 (2006.01) A61K 9/14 (2006.01) A61K 9/16 (2006.01)
Patent
CA 2190502
According to the present invention, methods and compositions are provided for spray-dried, interferon-based dry powder composit patticularly interferon-beta. The compositions are useful for treating conditions in humans that are responsive to treatment with interfe? ln pardcular, the methods of the present invention rely on spray drying to produce stable. high-potency dry powder formulation interferonns, including but not limited to IFN-beta. Surprisingly, it has been found that IFN can be prepared in high potency, dry po? formulations by spray drying. Such dry powder formulations find particular utility in the pulmonary delivery of INF.
Procédés et compositions permettant d'obtenir des compositions à base d'interféron sous forme de poudre séchée par pulvérisation, notamment à base d'interféron bêta. Ces compositions sont utiles dans le traitement de sujets sensibles au traitement par interférons. Les procédés ci-décrits se basent notamment sur le séchage par pulvérisation pour produire des formulations d'interférons sous forme de poudre sèche stables et de grande efficacité, comprenant entre autres l'IFN-bêta. On a découvert de manière inattendue que l'on peut préparer de l'IFN de grande efficacité sous forme de poudre séchée par pulvérisation. Ces formulations sont particulièrement utiles pour l'administration pulmonaire d'IFN.
Foster Linda C.
Kimura Shigenobu
Platz Robert M.
Satoh Yuichiro
Fetherstonhaugh & Co.
Nektar Therapeutics
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