Methods and compositions for the identification of...

Details Methods and compositions for the identification of... Methods and compositions for the identification of...

C - Chemistry, Metallurgy

12

P

167/129, 167/139

C12P 21/08 (2006.01) C07K 16/30 (2006.01) C12N 5/18 (2006.01) G01N 33/574 (2006.01) G01N 33/577 (2006.01) A61K 38/00 (2006.01) A61K 39/00 (2006.01)

Patent

CA 1307478

ABSTRACT Disclosed are monoclonal antibodies which react with human tumor cells, particularly metastatic human tumor cells, but not with normal human tissues tested. The monoclonal antibodies are prepared against a 580 kilodalton glycoprotein antigen, designated gp580, which is isolated from either rat or human tumor cells. Methods for isolating the glycoprotein antigen are disclosed as well. Moveover, techniques are disclosed for utilizing these antibodies both in the detection and in the prevention of human tumor lesions.

533286

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