C - Chemistry – Metallurgy – 07 – H
Patent
C - Chemistry, Metallurgy
07
H
C07H 15/252 (2006.01) C07H 1/00 (2006.01) C07H 15/207 (2006.01) C07H 15/24 (2006.01)
Patent
CA 2366681
The present invention discloses new and novel substituted anthracyclines with modified alkyl-aromatic ring substitutions on the C-3' of the sugar moiety or modified or unmodified alkyl-aromatic ring substitutions at the C-4' of the sugar moiety. It also discloses novel methods for the preparation of sugar substrates and methods for the preparation of anthracycline antibiotics. These anthracycline analogs show high cytotoxicity in vitro against several tumor cell lines.
L'invention concerne des nouvelles anthracyclines nouvellement substituées par une substitution sur le noyau alkyl-aromatique modifié, sur le C-3' de l'entité sucre, ou par une substitution de noyau alkyl-aromatique modifié ou non, sur le C-4' de l'entité sucre. L'invention concerne également des nouveaux procédés de préparation de substrats à base de sucre et des procédés de préparation d'antibiotiques du type anthracycline. Ces analogues d'anthracycline démontrent une cytotoxicité élevée in vitro à l'égard de plusieurs lignées cellulaires tumorales.
Fokt Izabella
Grynkiewicz Grzegorz
Krawczyk Marta
Perez-Soler Roman
Priebe Waldemar
Fokt Izabella
Goudreau Gage Dubuc
Grynkiewicz Grzegorz
Houston Pharmaceuticals Inc.
Krawczyk Marta
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