A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 39/395 (2006.01) A61K 38/17 (2006.01) C07K 14/725 (2006.01) C07K 16/16 (2006.01) C07K 16/18 (2006.01) C07K 16/42 (2006.01) A61K 38/00 (2006.01) A61K 39/00 (2006.01)
Patent
CA 2131898
2131898 9317703 PCTABS00025 The present invention provides novel compositions and methods useful in the modulation or selective suppression of host immune responses to an immunogen of interest, particularly to immunogens which are exogenous antigens or allergens. Subject compositions include antibody, antibody derived, and antibody-like molecules of primary antigen reactivity with respect to the immunogen of interest. Antibodies or antibody-like or antibody-derived molecules include antibody fragments such as Fab, and complementarily determining region peptides (CDRs) which may be grafted into a framework region of any species, particularly human. They also include human antibodies, derived from sensitized human lymphocytes produced by cell fusion with heterohybridomas, or by DNA cloning and expression. Other compositions include T cell receptor (TCR) molecules, obtained either from T cell clones or hybridomas or as purified TCR preparations. Immunoreactive peptides corresponding to some or all of the complementarily determining regions or hypervariable regions of the TCR are also employed.
Baldwin Robert W.
Byers Vera S.
Baldwin Robert W.
Byers Vera S.
Osler Hoskin & Harcourt Llp
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