Methods and compositions for the oral administration of...

Details Methods and compositions for the oral administration of... Methods and compositions for the oral administration of...

A - Human Necessities

61

K

A61K 31/44 (2006.01) A61P 1/04 (2006.01)

Patent

CA 2540977

Oral dosage forms, methods of treating diseases or adverse conditions, and methods of inhibiting gastric acid secretion related to prodrugs of a proton pump inhibitor are disclosed herein. Certain embodiments relate to the membrane permeability of the proton pump inhibitor and/or the membrane permeability of the prodrug. Other embodiments relate to prodrugs comprising an acidic functional group and a sulfonyl moiety. In other embodiments, the prodrug is a carboxylic acid which comprises a phenylsulfonyl moiety. Other embodiments relate to the pH of dosage forms and dosage forms comprising salts of acidic functional groups.

L'invention concerne des formes posologiques orales, des méthodes de traitement de maladies ou d'états indésirables et des méthodes d'inhibition de la sécrétion d'acide gastrique associées à des promédicaments d'un inhibiteur de la pompe à protons. Certains modes de réalisation concernent la perméabilité membranaire de l'inhibiteur de la pompe à protons et/ou la perméabilité membranaire du promédicament. D'autres modes de réalisation concernent des promédicaments comprenant un groupe fonctionnel acide et une partie sulfonyle. Selon d'autres modes de réalisation, ce promédicament est un acide carboxylique comprenant une partie phénylsulfonyle. Encore d'autres modes de réalisation se rapportent au pH de formes posologiques et à des formes posologiques comprenant des sels de groupes fonctionnels acides.

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