A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 31/445 (2006.01) A61K 31/16 (2006.01) A61K 31/165 (2006.01) A61K 31/195 (2006.01) A61K 31/4035 (2006.01) A61K 31/44 (2006.01) A61K 31/454 (2006.01) A61K 9/00 (2006.01)
Patent
CA 2395474
Methods and compositions for the prevention and treatment of all forms of atherosclerosis are described. Administration of compounds such as thalidomide, its analogs, hydrolysis products, metabolites, derivatives and precursors as well as additional compounds capable of inhibiting tumor necrosis factor .alpha. (TNF-.alpha.) are used in the invention. Also disclosed is the coating of prosthetic devices, such as stents, with the compounds of the invention for the prevention and/or treatment of restenosis.
L'invention concerne des méthodes et des compositions permettant de prévenir et de traiter toutes les formes d'athérosclérose. Les méthodes décrites dans la présente invention consistent à administrer des composés tels que le thalidomide, ses analogues, des produits d'hydrolyse, des métabolites, des dérivés et des précurseurs ainsi que d'autres composés capables d'inhiber le facteur de nécrose tumorale .alpha. (TNF-.alpha.). L'invention concerne également le revêtement d'appareillages prothétiques, tels que des stents, à l'aide des composés décrits dans l'invention, pour la prévention et/ou le traitement de la resténose.
Celgene Corp.
Smart & Biggar
LandOfFree
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