Methods and compositions for the prevention and treatment of...

Details Methods and compositions for the prevention and treatment of... Methods and compositions for the prevention and treatment of...

A - Human Necessities

61

K

A61K 38/22 (2006.01) A61K 38/18 (2006.01) A61P 7/00 (2006.01)

Patent

CA 2690018

Methods for increasing and maintaining hematocrit in a mammal comprising administering a hyperglycosylated analog of erythropoietin are disclosed. An analog may be administered less frequently than an equivalent molar amount of recombinant human erythropoietin to obtain a comparable target hematocrit and treat anemia. Alternatively, a lower molar amount of a hyperglycosylated analog may be administered to obtain a comparable target hematocrit and treat anemia. Also disclosed are new hyperglycosylated erythropoietin analogs, methods of production of the analogs, and compositions comprising the analogs.

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