Methods and compositions for the prevention and treatment of...

A - Human Necessities – 61 – K

Patent

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Details

A61K 48/00 (2006.01) A61K 31/04 (2006.01) A61K 31/165 (2006.01) A61K 31/275 (2006.01) A61K 31/405 (2006.01) A61K 31/445 (2006.01) A61K 31/565 (2006.01) A61K 31/7048 (2006.01) A61K 31/7056 (2006.01) A61K 31/7088 (2006.01) A61K 38/00 (2006.01) A61K 39/395 (2006.01) A61P 15/00 (2006.01) A61P 35/00 (2006.01) C12Q 1/02 (2006.01) C12Q 1/48 (2006.01) C12Q 1/68 (2006.01) G01N 33/50 (2006.01) G01N 33/574 (2006.01)

Patent

CA 2537765

The present invention relates to an association between specific polymorphisms of the COMT polypeptide and the development, or risk of developing, preterm labor and uterine diseases and conditions. Disclosed are therapeutic, preventative and diagnostic methods and compositions relating to pre-term labor, uterine diseases and conditions, and ovarian conditions and diseases. In certain embodiments, such methods and compositions involve a COMT inhibitor.

L'invention concerne une association entre des polymorphismes spécifiques du polypeptide COMT et le développement ou le risque de développer un accouchement prématuré et des maladies et des troubles utérins. L'invention concerne également des méthodes et des compositions thérapeutiques, préventives et diagnostiques concernant l'accouchement prématuré, les maladies et les troubles utérins, et les maladies et les troubles ovariens. Dans certains modes de réalisation, ces méthodes et ces compositions impliquent un inhibiteur de COMT.

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