A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 39/395 (2006.01) A61K 38/00 (2006.01) A61P 31/04 (2006.01)
Patent
CA 2524534
A method for preventing or treating sepsis by administering in conjunction a sepsis preventing or treating amount of one or more complement inhibitors and a sepsis preventing or treating amount of one or more CD14 pathway inhibitors to a patient. The complement inhibitors are preferably antibodies that bind to and inhibit complement proteins such as C5a and the CD14 pathway inhibitors are preferably antibodies that bind to and inhibit CD14 pathway components such as CD14 and LPS.
La présente invention concerne un procédé qui permet de prévenir ou traiter la sepsie en administrant à un patient un ou plusieurs inhibiteurs du complément dans une quantité permettant de prévenir ou traiter la sepsie, et un ou plusieurs inhibiteurs de la voie CD14 dans une quantité permettant de prévenir ou traiter la sepsie. Les inhibiteurs du complément sont de préférence des anticorps qui se lient aux protéines du complément telles que le C5a et les inhibent, et les inhibiteurs de la voie CD14 sont de préférence des anticorps qui se lient à des composants de la voie CD14 tels que le CD14 et le LPS et les inhibent.
Fung Sek Chung
Mollnes Tom Eirik
Genentech Inc.
Medinnova As
Sim & Mcburney
Tanox Inc.
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