Methods and compositions for the prevention or treatment of...

A - Human Necessities – 61 – K

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A61K 47/48 (2006.01) A61K 31/28 (2006.01) A61K 33/24 (2006.01) A61K 33/34 (2006.01) A61P 29/00 (2006.01) A61P 35/00 (2006.01)

Patent

CA 2341752

Provided are agents that can bind to copper, and form a tripartite complex with protein, and the use of these agents in the prevention and treatment of diseases with a vascular component, such as solid tumors. Compositions and methods for combination therapy of these diseases, including cancer, as well as therapeutic kits, are also provided.

La présente invention concerne d'une part des agents pouvant se lier au cuivre, et former un complexe tripartite avec une protéine, et d'autre part l'utilisation de ces agents pour prévenir ou traiter des maladies avec un composant vasculaire, comme les tumeurs solides, par exemple. Par ailleurs, cette invention concerne des compositions et des méthodes utilisés en traitement combiné pour ce type de maladies, notamment le cancer, ainsi que des kits thérapeutiques.

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