Methods and compositions for the regulation of vasoconstriction

Details Methods and compositions for the regulation of vasoconstriction Methods and compositions for the regulation of vasoconstriction

A - Human Necessities

61

K

A61K 38/46 (2006.01) A61K 31/192 (2006.01) A61K 38/17 (2006.01) A61K 38/18 (2006.01) A61K 38/19 (2006.01) A61K 38/49 (2006.01) A61K 49/00 (2006.01) C07K 1/00 (2006.01) C07K 14/705 (2006.01) C07K 16/00 (2006.01) C12N 9/14 (2006.01) G01N 33/53 (2006.01)

Patent

CA 2403220

Methods and compositions for the treatment of conditions which would benefit from vasoconstriction or the inhibition of vasoconstriction via modulation of sphingosine kinase and sphingosine-1-phosphate phosphatase activity and EDG receptor signaling are provided. These conditions include migraine, stroke, subarachnoid hemorrhage and vasospasm. Also provided are screening methods for modulators of sphingosine kinase and sphingosine-1-phosphate phosphatase activity and EDG receptor signaling which are capable of regulating vasoconstriction.

L'invention concerne des méthodes et des compositions de traitement d'états qui tireraient avantage d'une vasoconstriction ou de l'inhibition d'une vasoconstriction par la modulation de l'activité sphingosine kinase et sphingosine-1-phosphate phosphatase et signalisation du récepteur EDG. Ces états comprennent la migraine, l'ictus, l'hémorragie sous-arachnoïdienne et le spasme vasculaire. L'invention concerne également des méthodes de criblage de modulateurs de l'activité sphingosine kinase et sphingosine-1-phosphate phosphatase et de la signalisation du récepteur EDG lesquels sont capables de réguler la vasoconstriction.

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