Methods and compositions for the removal of viruses and uses...

Details Methods and compositions for the removal of viruses and uses... Methods and compositions for the removal of viruses and uses...

C - Chemistry, Metallurgy

12

N

C12N 7/02 (2006.01) A61K 39/385 (2006.01) A61L 2/02 (2006.01) C07K 14/15 (2006.01) C08B 5/14 (2006.01) C08B 37/00 (2006.01)

Patent

CA 2167392

Methods and compositions useful for the separation of viruses, including retroviruses and viral vectors, from preparations are disclosed. Sulfated oligosaccharides with at least about 6 µmoles sulfate per gram of oligosaccharide are provided. In one aspect, a sulfated oligosaccharide of the present invention may be used in purification of a virus, such as a lipid envelope virus. The present invention also discloses methods for the removal of a contaminating virus from a preparation, such as biologic therapeutic.

Procédés et compositions utiles pour la séparation de virus, y compris de rétrovirus et de vecteurs viraux, de préparations. Des oligosaccharides sulfatés ayant une teneur en sulfate d'au moins 6 mu moles environ par gramme d'oligosaccharide sont décrits. Dans un aspect, un oligosaccharide sulfaté de la présente invention peut être utilisé pour purifier un virus, tel qu'un virus enveloppe lipide. Des procédés d'élimination d'un virus contaminant d'une préparation, telle qu'une substance thérapeutique biologique, sont également décrits.

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