A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 39/00 (2006.01) A01N 33/12 (2006.01) A61K 39/12 (2006.01) A61L 2/00 (2006.01) C12N 7/00 (2006.01) C12N 7/04 (2006.01) C12N 7/06 (2006.01)
Patent
CA 2305182
Methods and compositions for selectively modifying nucleic acid molecules in biological compositions, including contacting the composition with an inactivating agent having formula (I), where each of R1, R2, R3, R4, R6, R7, and R8 is, independently, H or a monovalent hydrocarbon moiety containing between 1 and 4 carbon atoms, inclusive, provided that R1, R2, R3, R4, R6, R7, and R8 cannot all be H; R5 is a divalent hydrocarbon moiety containing between 2 and 4 carbon atoms, inclusive; X is a pharmaceutically acceptable counter- ion; and n is an integer between 1 and 10, inclusive, are disclosed.
L'invention concerne des procédés et des compositions permettant de modifier de manière sélective des molécules d'acides nucléiques dans des compositions biologiques, y compris par contact entre les compositions décrites et un agent d'inactivation représenté par la formule (I). Dans ladite formule, R¿1?, R¿2?, R¿3?, R¿4?, R¿6?, R¿7? et R¿8? sont chacun indépendamment H ou une fraction hydrocarbure monovalente renfermant entre 1 et 4 atomes de carbone, quatrième atome compris, à condition que, R¿1?, R¿2?, R¿3?, R¿4?, R¿6?, R¿7? et R¿8? ne puissent pas tous être H; R¿5? est une fraction hydrocarbure divalente renfermant entre 2 et 4 atomes de carbone, quatrième atome compris; X est un contre-ion pharmaceutiquement acceptable; et n est un entier compris entre 1 et 10, entier 10 compris.
Ackerman Samuel K.
Budowsky Edward I.
Edson Clark M.
Purmal Andrei A.
Mbm Intellectual Property Law Llp
Panacos Pharmaceuticals Inc.
Pentose Pharmaceuticals Inc.
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