Methods and compositions for the specific inhibition of kras...

Details Methods and compositions for the specific inhibition of kras... Methods and compositions for the specific inhibition of kras...

C - Chemistry, Metallurgy

12

N

C12N 15/113 (2010.01) A61K 31/713 (2006.01) A61P 35/00 (2006.01) C12N 5/09 (2010.01) C07H 21/02 (2006.01) C12N 15/55 (2006.01)

Patent

CA 2757613

This invention relates to compounds, compositions, and methods useful for reducing KRAS target RNA and pro-tein levels via use of Dicer substrate siRNA (DsiRNA) agents possessing asymmetric end structures.

Cette invention porte sur des composés, des compositions et des procédés utiles pour réduire l'ARN cible KRAS et les taux de protéine KRAS par l'intermédiaire de l'utilisation d'agents d'ARNsi (ARNDsi) substrat de Dicer possédant des structures terminales asymétriques.

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