A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 48/00 (2006.01) A61K 31/7088 (2006.01) A61K 38/16 (2006.01) A61P 35/00 (2006.01) C07K 14/075 (2006.01) C07K 14/71 (2006.01) A61K 38/00 (2006.01)
Patent
CA 2096723
Disclosed are methods and compositions for the suppression of expression of the neu oncogene, as well as suppression of neu oncogene-mediated transformation, tumorigenesis and metastasis. The method disclosed involved introduction of adenovirus early 1A gene-(the E1A gene) products into affected cells. These products, which are preferably introduced by transfection of the E1A gene into affected cells, serve to suppress neu gene expression as measured by a reduction of p185 expression. Furthermore, the E1A gene products surprisingly serve to suppress the oncogenic phenotype, as indicated by a reduction in cell growth, growth in soft agar, as well as tumorigenic and metastatic potential in vivo. The inventors propose that E1A gene products, or derivatives therefrom, may ultimately be employed as treatment modalities for neu-mediated cancers, such as cancers of the female genital tract and breast.
Hung Mien-Chie
Yu Di-Hua
Bereskin & Parr
The Board Of Regents Of The University Of Texas System
LandOfFree
Methods and compositions for the suppression of neu mediated... does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Methods and compositions for the suppression of neu mediated..., we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Methods and compositions for the suppression of neu mediated... will most certainly appreciate the feedback.
Profile ID: LFCA-PAI-O-1737627