Methods and compositions for the targeting of a systemic...

A - Human Necessities – 61 – K

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A61K 39/00 (2006.01) A61K 35/66 (2006.01) A61K 48/00 (2006.01) A61P 37/04 (2006.01) C07K 14/535 (2006.01) C12N 15/63 (2006.01) C12N 15/85 (2006.01)

Patent

CA 2474728

The invention provides methods and compositions for targeting a separately generated immune response to a specific organ or tissue; e.g. one affected by cancer, using one or more agents with a tropism for the organ or tissue r that can be specifically localized to the desired organ or tissue. For example, the invention provides methods and compositions for treating liver metastases from colorectal cancer using a combination of a granulocyte/macrophage colony stimulating factor (GM-CSF) augmented tumor cell vaccination and Listeria monocytogenes (LM) infection.

L'invention concerne des procédés et des compositions de ciblage d'une réponse immunitaire générée séparément contre un organe ou un tissu spécifique, par exemple un tissu ou un organe touché par le cancer, au moyen d'un ou de plusieurs agents provoquant un tropisme dans l'organe ou dans le tissu, et qui peut être spécifiquement positionné dans l'organe ou dans le tissu recherché. L'invention concerne, par exemple, des procédés et des compositions de traitement de métastases du foie, provenant d'un cancer colorectal, au moyen d'une combinaison d'un vaccin de cellule tumorale activée exprimant le facteur de stimulation de colonies de granulocytes/macrophages (GM-CSF) et d'une infection par <i>Listeria monocytogenes</i> (LM).

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