Methods and compositions for the treatment and prevention of...

C - Chemistry – Metallurgy – 12 – N

Patent

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Details

C12N 15/62 (2006.01) A61K 38/21 (2006.01) A61P 31/18 (2006.01) C07K 14/47 (2006.01) C12N 15/12 (2006.01) C12N 15/63 (2006.01) C12P 21/02 (2006.01) C12Q 1/00 (2006.01) C12Q 1/68 (2006.01)

Patent

CA 2557500

The invention provides novel TRIM polypeptides, proteins, and nucleic acid molecules. In addition to isolated, full-length TRIM proteins, the invention further provides isolated TRIM fusion proteins, antigenic peptides and anti- TRIM antibodies. The invention also provides TRIM nucleic acid molecules, recombinant expression vectors containing a nucleic acid molecule of the invention, host cells into which the expression vectors have been introduced and non-human transgenic animals in which an TRIM gene has been introduced or disrupted. The present invention also provides methods and compositions for the diagnosis and treatment of viral infection and/or replication, e.g., HIV infection. The invention further provides methods for identifying a compound capable of treating or preventing viral infection and/or replication, e.g., HIV infection and AIDS. In addition, the invention provides a method for treating a subject having a viral infection and/or replication, e.g., HIV infection using the modulators of the invention.

L'invention concerne des nouveaux polypeptides, des nouvelles protéines, et molécules d'acide nucléique TRIM. Outre des protéines TRIM pleine longueur isolées, l'invention concerne des protéines de fusion TRIM isolées, des peptides antigéniques et des anticorps anti-TRIM. L'invention concerne également des molécules d'acide nucléique TRIM, des vecteurs d'expression recombinés contenant une molécule d'acide nucléique de l'invention, des cellules hôtes dans lesquelles les vecteurs d'expression ont été introduits et des animaux transgéniques non humains dans lesquels un gène TRIM a été introduit ou perturbé. L'invention concerne également des méthodes et des compositions pour le diagnostic et le traitement d'une infection virale et/ou d'une réplication, par exemple, une infection par le VIH. L'invention concerne en outre des méthodes d'identification d'un composé permettant de traiter ou de prévenir une infection virale et/ou une réplication, par exemple, une infection par le VIH et le SIDA. L'invention concerne également une méthode de traitement d'un sujet souffrant d'une infection virale et/ou d'une réplication, par exemple, une infection par le VIH, au moyen des modulateurs de l'invention.

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