A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 38/00 (2006.01) A61K 38/02 (2006.01) C07K 2/00 (2006.01) C07K 7/08 (2006.01)
Patent
CA 2529307
Compositions and related methods for treating IBS and other gastrointestinal disorders and conditions (e.g., gastrointestinal motility disorders, functional gastrointestinal disorders, gastroesophageal reflux disease (GERD), duodenogastric reflux, Crohn's disease, ulcerative colitis, inflammatory bowel disease, functional heartburn, dyspepsia (including functional dyspepsia or nonulcer dyspepsia), gastroparesis, chronic intestinal pseudo-obstruction (or colonic pseudoobstruction), and disorders and conditions associated with constipation, e.g., constipation associated with use of opiate pain killers, post-surgical constipation, and constipation associated with neuropathic disorders as well as other conditions and disorders are described. The compositions feature peptides that activate the guanylate cyclase C (GC-C) receptor.
L'invention concerne des compositions et des méthodes associées pour traiter le syndrome du colon irritable et d'autres troubles gastro-intestinaux et pathologies associées, par exemple, des troubles de motilité gastro-intestinale, des troubles gastro-intestinaux fonctionnels, des maladies de reflux gastro-oesophagien (GERD), de reflux duodénogastrique, la maladie de Crohn, la colite ulcéreuse, une maladie intestinale inflammatoire, des aigreurs d'estomac fonctionnelles, une dyspepsie (notamment dyspepsie fonctionnelle ou dyspepsie non ulcéreuse), une gastroparèse, une pseudo-obstruction intestinale chronique (ou une pseudo-obstruction colonique), et des troubles et pathologies associés à la constipation, par exemple, constipation associée à l'utilisation de médicaments anti-douleurs opiacés, à la constipation post-chirurgicale, à la constipation associée à des troubles neuropathiques, ainsi qu'à d'autres troubles analogues. Les compositions comportent des peptides activant le récepteur de la guanylate cyclase C (GC-C).
Currie Mark G.
Li Jing Sun
Mahajan-Miklos Shalina
Ironwood Pharmaceuticals Inc.
Microbia Inc.
Smart & Biggar
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