G - Physics – 01 – N
Patent
G - Physics
01
N
G01N 33/566 (2006.01) A61K 31/443 (2006.01)
Patent
CA 2596873
The invention provides a method of identifying a niacin receptor modulator with reduced flushing effect compared to niacin or a niacin analog, comprising determining the MAP kinase activity of said modulator, wherein a decrease in MAP kinase activity induced by said modulator compared to MAP kinase activity induced by niacin or a niacin analog indicates that said modulator has reduced flushing effect when compared to niacin or a niacin analog.
Procédé d'identification de modulateur de récepteur de niacine avec effet de rinçage réduit par rapport à la niacine ou à un analogue de niacine qui consiste à déterminer l'activité MAP kinase du modulateur, sachant qu'une baisse de l'activité en question induite par le modulateur par rapport à l'activé induite par la niacine ou un analogue de niacine indique que le modulateur a un effet de rinçage réduit par rapport à la niacine ou à un analogue de niacine
Connolly Daniel T.
Kanemitsu-Parks Martha
Maciejewski-Lenoir Dominique
Richman Jeremy G.
Arena Pharmaceuticals Inc.
Smart & Biggar
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