C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
C12N 15/13 (2006.01) A61K 39/395 (2006.01) C07K 14/47 (2006.01) C07K 16/18 (2006.01) C12N 5/20 (2006.01) G01N 33/53 (2006.01) A61K 38/00 (2006.01)
Patent
CA 2189015
The use of anti-C5 antibodies, e.g., monoclonal antibodies, to treat glomerulonephritis (GN) is disclosed. The administration of such antibodies at low dosage levels has been found to significantly reduce glomerular inflammation/enlargement and other pathologic conditions associated with GN. Also disclosed are novel anti-C5 antibodies and anti-C5 antibody-encoding nucleic acid molecules. These antibodies are useful in the treatment of GN and other inflammatory conditions involving pathologic activation of the complement system.
L'invention se rapporte à l'utilisation d'anticorps anti-C5, tels que des anticorps monoclonaux, pour traiter la glomérulonéphrite (GN). L'administration de ces anticorps à de faibles taux de dosage s'est avérée réduire d'une façon significative l'inflammation/le développement glomérulaire et autres états pathologiques associés à GN. L'invention se rapporte également à de nouveaux anticorps anti-C5 et à des molécules d'acide nucléique codant les anticorps anti-C5. Ces anticorps sont utilisés dans le traitement de GN et d'autres états inflammatoires impliquant une activation pathologique du système du complément.
Evans Mark J.
Matis Louis
Mueller Eileen
Nye Steven H.
Rollins Scott
Alexion Pharmaceuticals Inc.
Mcfadden Fincham
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