A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 38/10 (2006.01) C07K 7/08 (2006.01)
Patent
CA 2596505
Compositions and related methods for treating IBS and other gastrointestinal disorders and conditions (e.g., gastrointestinal motility disorders, functional gastrointestinal disorders, gastroesophageal reflux disease (GERD), duodenogastric reflux, Crohn's disease, ulcerative colitis, inflammatory bowel disease, functional heartburn, dyspepsia (including functional dyspepsia or nonulcer dyspepsia), gastroparesis, chronic intestinal pseudo-obstruction (or colonic pseudoobstruction), and disorders and conditions associated with constipation, e.g., constipation associated with use of opiate pain killers, post-surgical constipation, and constipation associated with neuropathic disorders as well as other conditions and disorders are described. The compositions feature peptides that activate the guanylate cyclase C (GC-C) receptor.
L'invention concerne des compositions et des procédés associés permettant de traiter le syndrome du côlon irritable (IBS) et d'autres troubles et états gastro-intestinaux (par exemple les troubles de la motilité gastro-intestinale, les troubles gastro-intestinaux fonctionnels, le reflux gastrooesophagien pathologique (GERD), le reflux duodénogastrique, la maladie de Crohn, la recto-colite ulcéro-hémorragique, la maladie intestinale inflammatoire, les aigreurs fonctionnelles, la dyspepsie (y compris la dyspepsie fonctionnelle ou la dyspepsie sans ulcère), la gastroparésie, la pseudo-obstruction intestinale chronique (ou pseudo-obstruction colique), et les troubles et états associés à la constipation, par exemple la constipation liée à l'utilisation d'analgésiques opiacés, la constipation post-chirurgicale, la constipation liée à des troubles neuropathiques, ainsi que d'autres états et troubles. Les compositions comportent des peptides qui activent le récepteur guanylate cyclase C (GC-C).
Currie Mark G.
Kurtz Caroline
Mahajan-Miklos Shalina
Sun Li Jing
Microbia Inc.
Smart & Biggar
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