A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 33/24 (2006.01) A61K 31/13 (2006.01) A61K 31/335 (2006.01) A61K 31/34 (2006.01) A61K 31/40 (2006.01) A61K 31/505 (2006.01) A61K 31/70 (2006.01) A61K 47/10 (2006.01) A61K 47/44 (2006.01)
Patent
CA 2180260
Methods and compositions are provided for the treatment of a hostwith a cellular proliferative disease, particularly a neoplasia. In the subject methods, a pharmaceutically acceptable, substantially anhydrous, injectable semi-solid composition which acts as a depot for a cytostatic agent, is administered to a lesion of the disease, particularly intralesionally. The subject compositions comprise a water immiscible, fatty acid ester matrix and a cytostatic agent.
L'invention concerne des procédés et des compositions utilisés dans le traitement d'un hôte affecté par une maladie à prolifération cellulaire, notamment une néoplasie. Dans ces procédés, une composition semi-solide injectable, pratiquement anhydre, et pharmaceutiquement acceptable, retient un agent cytostatique en vue de la libération lente de celui-ci, et est administrée à un site d'une lésion pathologique, notamment par voie intralésionnelle. Ces compositions comprennent une matrice d'ester d'acide gras, non miscible dans l'eau et un agent cytostatique.
Brown Dennis M.
Jones Richard E.
Maskiewicz Richard
Michaels Shawnya J.
Intarcia Therapeutics Inc.
Ledgley Law
Matrix Pharmaceutical Inc.
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