Methods and compositions for the treatment of alopecia and...

Details Methods and compositions for the treatment of alopecia and... Methods and compositions for the treatment of alopecia and...

A - Human Necessities

61

K

A61K 31/155 (2006.01) A61K 31/00 (2006.01) A61K 31/426 (2006.01) A61K 31/427 (2006.01) A61K 31/433 (2006.01) A61K 31/4439 (2006.01) A61K 31/7004 (2006.01) A61K 45/06 (2006.01) A61P 17/10 (2006.01) A61P 17/14 (2006.01)

Patent

CA 2406871

Insulin sensitivity increasing substances (ISIS), including but not limited to D-chiro-inositol, thiazolidinedione and derivatives, and biguanides, are useful in the treatment of hair loss and other disorders of the pilosebaceous apparatus (hirsutism, acne, etc.) associated with conditions of excess insulin and/or insulin resistance. The treatment comprises administering to a mammal, such as a human, at least one ISIS either alone or in combination with at least one agent, such as an androgen receptor blocker (ARB) and/or a steroid enzyme inhibitor or inducer (STI). Additionally, an activity enhancing agent may be included for topical administration.

L'invention concerne des substances augmentant la sensibilité à l'insuline (ISIS), y compris, entres autre, le D-chiro-inositol, la thiazolidinedione et ses dérivés, et les biguanides, qui sont utilisées dans le traitement de la perte de cheveux et d'autres troubles de l'appareil pilosébacé (hirsutisme, acné, etc.) associés à l'excès d'insuline et/ou à la résistance à l'insuline. Le traitement consiste à administrer à un mammifère, par exemple à l'homme, au moins une ISIS seule ou en combinaison avec au moins un agent, par exemple un inhibiteur d'androgènes (ARB) et/ou un inhibiteur ou inducteur d'enzymes stéroïdes (STI). De plus, un agent stimulant l'activité peut être inclus pour une administration par voie topique.

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