Methods and compositions for the treatment of b cell...

Details Methods and compositions for the treatment of b cell... Methods and compositions for the treatment of b cell...

A - Human Necessities

61

K

A61K 38/16 (2006.01) A61K 36/48 (2006.01) A61P 35/00 (2006.01) C07K 14/42 (2006.01)

Patent

CA 2545709

The ability of certain members of the FRIL family of proteins to inhibit the proliferation and/or survival of FRIL-sensitive cancer cells is disclosed. The FRIL proteins can be used in methods of treatment for such FRIL-sensitive cancers, in the manufacture of medicaments for the treatment of such cancers, and for imaging, detecting or locating such cancers. FRIL-sensitive cancers include, without limitation, B cell lymphomas and T cell cutaneous lymphomas.

Cette invention décrit la capacité de certains membres de la famille FRIL de protéines d'inhiber la prolifération et/ou la survie des cellules cancéreuses sensibles aux protéines FRIL. Les protéines FRIL peuvent être utilisées dans des procédés pour traiter ces cancers sensibles aux protéines FRIL, dans la fabrication de médicaments pour traiter ces cancers, et dans l'imagerie, la détection ou la localisation de ces cancers. Les cancers sensibles aux protéines FRIL sont notamment les lymphomes des lymphocytes B et les lymphomes cutanés des lymphocytes T.

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