Methods and compositions for the treatment of cancer

Details Methods and compositions for the treatment of cancer Methods and compositions for the treatment of cancer

A - Human Necessities

61

K

A61K 45/06 (2006.01) A61P 35/00 (2006.01) C12Q 1/34 (2006.01)

Patent

CA 2737551

The invention relates to compositions comprising an acid ceramidase inhibitor and a choline kinase inhibitor as well as to the uses thereof for the treatment of cancer. The invention also relates to methods for the selection of an individualised therapy of a cancer patient based on the detection of the acid ceramidase levels. Moreover, the invention also relates to compositions comprising a choline kinase inhibitor and a chemotherapeutic agent and uses thereof for the treatment of cancer. Finally, the invention also relates to compositions comprising a choline kinase inhibitor and a death receptor ligand and uses thereof for the treatment of cancer.

La présente invention concerne des compositions comprenant un inhibiteur de céramidase acide et un inhibiteur de choline kinase ainsi que les utilisations de celles-ci pour le traitement du cancer. L'invention concerne en outre des procédés pour la sélection d'une thérapie individualisée d'un patient cancéreux basée sur la détection des taux de céramidase acide. De plus, l'invention concerne en outre des compositions comprenant un inhibiteur de choline kinase et un agent chimiothérapeutique et les utilisations de celles-ci pour le traitement du cancer. Enfin, l'invention concerne en outre des compositions comprenant un inhibiteur de choline kinase et un ligand de récepteur de mort et des utilisations de celles-ci pour le traitement du cancer.

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