Methods and compositions for the treatment of cirrhosis and...

A - Human Necessities – 61 – K

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A61K 48/00 (2006.01) C07K 14/65 (2006.01) C12N 15/86 (2006.01) C12N 15/864 (2006.01)

Patent

CA 2756596

The invention provides a method for the treatment of cirrhosis and liver fibrosis by the use or viral vectors containing the gene encoding IGF-I. The invention discloses both parvoviral vectors and SV40-based vectors as well uses thereof for the treatment of cirrhosis and gene therapy and methods for the preparation of said viral vectors.

L'invention concerne une méthode pour le traitement de la cirrhose et de la fibrose hépatique à travers l'utilisation de vecteurs viraux qui contiennent le gène qui code pour l'IGF-1. L'invention concerne aussi bien des vecteurs parvoviraux que des vecteurs à base de SV40 ainsi que leurs utilisations pour le traitement de la cirrhose et pour la thérapie génique et des méthodes pour la préparation desdits vecteurs viraux.

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