A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 31/519 (2006.01) A61P 9/10 (2006.01) A61P 9/12 (2006.01)
Patent
CA 2631740
The present invention is directed to a novel methods and compositions for the therapeutic intervention of vascular complications associated with diabetes, hyperlipidemias, and various cardiovascular disorders including but not limited to recalcitrant hypertension, coronary artery disease, pulmonary arterial hypertension, congestive heart failure, and hemolytic anemias. More specifically, the specification describes methods and compositions for treating such vascular disorders using compositions comprising BH4 and derivative thereof. Combination therapies of BH4 and other therapeutic regimens are contemplated.
La présente invention concerne de nouveaux procédés et de nouvelles compositions pour le traitement thérapeutique de complications vasculaires associées au diabète, aux hyperlipidémies et à différents troubles cardiovasculaires dont, mais sans y être limités, l'hypertension récalcitrante, une maladie coronarienne, l'hypertension artérielle pulmonaire, l'insuffisance cardiaque congestive et des anémies hémolytiques. Plus précisément, la présente invention concerne des procédés et des compositions servant à traiter de tels troubles vasculaires en utilisant des compositions comprenant de la BH4 ou un dérivé de celle-ci. L'invention concerne également des thérapies combinées de la BH4 et d'autres régimes thérapeutiques.
Dorenbaum Alejandro
Kakkis Emil D.
Oppenheimer Daniel I.
Biomarin Pharmaceutical Inc.
Kirby Eades Gale Baker
LandOfFree
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