Methods and compositions for the treatment of diseases or...

A - Human Necessities – 61 – K

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Details

A61K 31/573 (2006.01) A61K 31/519 (2006.01) A61K 31/5377 (2006.01) A61K 31/675 (2006.01) A61K 45/06 (2006.01) A61P 1/02 (2006.01)

Patent

CA 2652773

The invention features methods and compositions for reducing the serum C-reactive protein (CRP), IL-6, and/or IFN-.gamma. levels in a patient in need thereof, and for treating diseases and conditions associated with an increased serum CRP, IL-6, and/or IFN-.gamma. levels. The invention also features methods and compositions for treating a patient diagnosed with, or at risk of developing, periodontal disease by administering a corticosteroid or an analog thereof and/or a tetra-substituted pyrimidopyrimidine or an adenosine analog upregulator.

L'invention concerne des méthodes et des compositions destinées à réduire les taux sériques de protéine C réactive (CRP), d'IL-6 et/ou d'IFN-.gamma. chez un patient nécessitant un tel traitement, et à traiter des maladies et des affections associées à des taux sériques accrus de CRP, d'IL-6 et/ou d'IFN-.gamma.. L'invention concerne également des méthodes et des compositions destinées à traiter un patient chez qui on a diagnostiqué une parodontopathie ou qui présente un risque de développer cette maladie, par administration d'un corticostéroïde ou d'un analogue de celui-ci et/ou d'une pyrimidopyrimidine tétra-substituée ou d'un régulateur positif de l'activité de l'adénosine.

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