A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 38/17 (2006.01) C07K 14/47 (2006.01) C07K 14/705 (2006.01) G01N 33/53 (2006.01)
Patent
CA 2405946
The present invention provides methods and compositions to treat fibrotic conditions, to increase lymphocyte production in vivo, and to improve and/or normalize lung function, pulmonary compliance, blood oxygenation, and blood pH to inhibit inflammatory processes to stimulate or inhibit pro-inflammatory and immune cells, and to inhibit migration of vascular endothelial cells. The invention contemplates the administration of human uteroglobin, native or recombinant, as a means of achieving these ends. Specifically, it has been found that uteroglobin inhibits cell adhesion to fibronectin, increases lymphocyte production in vivo, and improves and/or normalizes lung function, pulmonary compliance, blood oxygenation, and blood pH, and inhibits inflammatory process. In addition it has been found that uteroglobin can stimulate or inhibit pro-inflammatory and immune cells and inhibitor migration of vascular endothelial cells.
L'invention concerne des procédés et compositions servant à traiter des états fibreux, à augmenter <i>in vivo</i> la production de lymphocytes et à améliorer et/ou normaliser la fonction pulmonaire, la compliance pulmonaire, l'oxygénation sanguine et le pH sanguin, de manière à inhiber des processus inflammatoires afin de stimuler ou inhiber des cellules pro-inflammatoires et immunes, et à inhiber la migration des cellules endothéliales vasculaires. A cette fin, l'invention consiste à administrer de l'utéroglobine humaine, naturelle ou recombinée. On a notamment trouvé que l'utéroglobine inhibait l'adhésion cellulaire à la fibronectine, augmentait la production de lymphocytes in vivo et améliorait et/ou normalisait la fonction pulmonaire, la compliance pulmonaire, l'oxygénation sanguine et le pH sanguin, et inhibait le processus inflammatoire. En outre, on a trouvé que l'utéroglobine pouvait stimuler ou inhiber des cellules pro-inflammatoires et immunes et inhiber la migration de cellules endothéliales vasculaires.
Antico Giovanni
Farrow Jeffrey
Lohnas Gerald
Melby James
Miele Lucio
Claragen Inc.
Clarassance Inc.
Smart & Biggar
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