Methods and compositions for the treatment of graft failure

A - Human Necessities – 61 – K

Patent

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Details

A61K 31/165 (2006.01) A61K 31/505 (2006.01) A61K 31/506 (2006.01) A61K 38/21 (2006.01) A61K 45/06 (2006.01)

Patent

CA 2490989

The present invention provides methods and compositions for treating graft failure resulting from neointimal hyperplasia. These methods and compositions feature the use of platelet derived growth factor receptor (PDGFR) inhibitor compounds, such as N-phenyl-2-pyrimidine compounds (e.g., imatinib mesylate) to inhibit the biological activity of the PDGFR.

L'invention concerne des méthodes et des compositions de traitement du rejet de greffe consécutif à l'hyperplasie néointimale. Ces méthodes et compositions consistent à utiliser des composés inhibiteurs du récepteur du facteur de croissance dérivé des plaquettes (PDGFR), tels que les composés N-phényl-2-pyrimidine (par exemple, le mésylate d'imatinibe), pour inhiber l'activité biologique du PDGFR.

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