Methods and compositions for the treatment of helicobacter...

A - Human Necessities – 61 – K

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A61K 31/335 (2006.01)

Patent

CA 2546210

The present invention relates to methods and compositions for treating pathological conditions associated with ferrous-dependent bacteria, such as, Helicobacter pylori in which high intracellular ferrous iron concentration is required for their survival and pathogenesis. The compositions of the invention comprise endoperoxide bridge-containing compounds that specifically inhibit the growth of the ferrous-dependent bacteria and preferably promote the eradication of the bacteria. The compositions, typically also include at least one active agents for treating Helicobacter sp -related gastrointestinal disorders, such as a proton pump inhibitor, an H2 blocker or a bismuth- containing compound.

Procédés et compositions destinés au traitement d'états pathologiques associés à des bactéries dépendantes du fer ferreux, telles que l'Helicobacter pylori, dont la survie et la pathogenèse nécessitent une concentration élevée en fer ferreux intracellulaire. Les compositions selon l'invention comportent des composés contenant un pont endoperoxyde qui inhibent de manière spécifique la croissance des bactéries dépendantes du fer ferreux et qui favorisent de préférence l'éradication desdites bactéries. Ces compositions comprennent aussi généralement au moins un agent actif permettant de traiter des troubles gastro-intestinaux liés à l'Helicobacter sp, tel qu'un inhibiteur de pompe à protons, un bloqueur H2 ou un composé contenant du bismuth.

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