C - Chemistry – Metallurgy – 12 – Q
Patent
C - Chemistry, Metallurgy
12
Q
C12Q 1/48 (2006.01) A61P 29/00 (2006.01) C12Q 1/68 (2006.01)
Patent
CA 2424246
The present invention is directed to compositions and methods for treating inflammatory diseases comprising administration of compositions that effect glycogen synthase kinase 3.beta. (GSK-3.beta.) protein or gene. The present invention also comprises methods and compositions for the identification of compounds or therapeutic agents which modulate the activity of the protein. The present invention provides compositions for and methods off treatment of biological conditions including, but not limited to, type I and type II diabetic induced vasculopathy, other vasculopathies, asthma and inflammation- induced diseases such as atherosclerosis and cell proliferation.
La présente invention concerne des compositions et des méthodes pour traiter des maladies inflammatoires, consistant à administrer lesdites compositions qui agissent sur la protéine ou le gène de la glycogène synthase kinase 3.beta. (GSK-3.beta.). La présente invention concerne également des méthodes et des compositions pour identifier des composés ou agents thérapeutiques qui modulent l'activité de ladite protéine ainsi que des compositions et des méthodes pour traiter des états biologiques parmi lesquels figurent notamment la vasculopathie diabétique de types I et II, d'autres vasculopathies, l'asthme et des maladies inflammatoires telles que l'athérosclérose et la prolifération cellulaire.
Cahoon Shianlen
Pillarisetti Sivaram
Saxena Uday
Vines Angela
Cahoon Shianlen
Finlayson & Singlehurst
Pillarisetti Sivaram
Reddy Us Therapeutics Inc.
Saxena Uday
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