Methods and compositions for the treatment of malignancies...

Details Methods and compositions for the treatment of malignancies... Methods and compositions for the treatment of malignancies...

C - Chemistry, Metallurgy

12

N

C12N 15/55 (2006.01) A61K 31/70 (2006.01) A61K 48/00 (2006.01) C12N 9/16 (2006.01) C12N 15/86 (2006.01)

Patent

CA 2078010

2078010 9113989 PCTABS00007 Methods and compositions are disclosed for the treatment of malignancies in which a protein tyrosine kinase is associated. The malignancies may be treated with a gene transfer vehicle capable of infecting malignant cells, wherein the gene transfer vehicle carries a DNA construct comprising a DNA sequence encoding a protein tyrosine phosphatase (PTPase). Suitable DNA sequences include those encoding wild type, or carboxyl terminus truncated, PTPases.

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