A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 31/195 (2006.01) A61K 31/137 (2006.01) A61K 31/138 (2006.01) A61P 9/04 (2006.01)
Patent
CA 2561390
The present invention relates to methods for the treatment of conditions characterised by abnormalities of myocardial cell ion levels, such as Na+, K+ and Ca2+ ions. The present invention also relates to methods of treatment of heart failure and myocardial hypertrophy. The invention also relates to compounds and compositions, such as .beta.3 adrenoceptor agonists, useful in the treatment of mammals, particularly humans, having a condition characterised by abnormalities of myocardial cell ion levels, such as Na+, K+ and Ca2+ ions, including heart failure and myocardial hypertrophy.
La présente invention concerne des méthodes de traitement d'états caractérisés par des anomalies des niveaux d'ions dans les cellules myocardiques tels que les ions Na?+¿, K?+¿ et Ca?2+¿. La présente invention concerne également des méthodes de traitement de l'insuffisance cardiaque et de l'hypertrophie du myocarde. L'invention concerne également des composés et des compositions, tels que des agonistes de l'adrénocepteur .beta.¿3?, utiles dans le traitement de mammifères, notamment de sujets humains présentant un état caractérisé par des anomalies des niveaux d'ions dans les cellules du myocarde, tels que les ions Na?+¿, K?+¿ et Ca?2+¿, notamment l'insuffisance cardiaque et l'hypertrophie du myocarde.
Bundgaard Henning
Rasmussen Helge H.
Fasken Martineau Dumoulin Llp
Northern Sydney And Central Coast Area Health Service
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