Methods and compositions for the treatment of neurological...

A - Human Necessities – 61 – K

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A61K 48/00 (2006.01) C12N 15/85 (2006.01) C12N 15/86 (2006.01) C12N 15/861 (2006.01) C12N 15/864 (2006.01) C12N 15/869 (2006.01)

Patent

CA 2542417

The present invention relates to a method for delivering a nucleic acid sequence encoding neuropeptide Y, or a derivative or functional fragment thereof, to a mammalian nervous system target cell. The expression of exogenous NPY, or a derivative or a functional fragment thereof in the target cell(s) provides therapeutic benefit for subjects afflicted with a neurological disorder.

La présente invention porte sur une méthode d'administration d'une séquence d'acides nucléiques codant un neuropeptide Y ou d'un dérivé ou de son fragment fonctionnel, sur une cellule cible d'un système nerveux d'un mammifère. L'expression de NPY exogène, ou d'un dérivé ou de son fragment fonctionnel, dans la(les) cellules cibles présente un avantage thérapeutique pour les patients souffrant d'un trouble neurologique.

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