A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 38/00 (2006.01)
Patent
CA 2514942
The present invention provides novel methods for the treatment of Parkinson~s disease and other .alpha.-synucleinopathies. The methods of the invention include treatment with inhibitors of transglutaminase, which can inhibit aggregation of .alpha.-synuclein. Also provided are screening assays for novel inhibitors of transglutaminase which may be used in the treatment of Parkinson~s disease and other .alpha.-synucleinopathies.
La présente invention concerne de nouvelles méthodes de traitement de la maladie de Parkinson et d'autres .alpha.-synucléinopathies. Les méthodes de traitement de l'invention consistent à utiliser des inhibiteurs de la transglutaminase, pouvant inhiber l'agrégation de la .alpha.-synucléine. L'invention concerne également des analyses de criblage de nouveaux inhibiteurs de la transglutaminase, pouvant être utilisés dans le traitement de la maladie de Parkinson et d'autres .alpha.-synucléinopathies.
Junn Eunsung
Mouradian M. Maral
Bereskin & Parr Llp/s.e.n.c.r.l.,s.r.l.
Department Of Health And Human Services Government Of The United States Of America As Represented By The
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