A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 38/18 (2006.01) A61P 9/10 (2006.01) C07K 14/50 (2006.01)
Patent
CA 2414020
Compositions and methods for treating peripheral artery disease in a patient are provided. Compositions comprise recombinant fibroblast growth factor-2. Fibroblast growth factor, such as FGF-2, is administered in therapeutically effective amounts to treat or prevent peripheral artery disease including claudication and critical limb ischemia. Pharmaceutical compositions comprising a therapeutically effective amount of FGF-2 and a pharmaceutically acceptable carrier are also provided. The methods of the invention to treat peripheral artery disease and claudication comprise administering at least a single dose of a pharmaceutical composition comprising the FGF, such as FGF-2, via intra-arterial, intravenous, or intramuscular infusion to the patient. It is recognized that increased benefits may result from multiple dosing, including intermittent dosing.
L'invention porte sur des préparations et des procédés de traitement des lésions des artères périphériques à base de facteur de croissance fibroblastique N·2 (FGF-2) qui s'administre à des doses à effet thérapeutique pour traiter ou prévenir lesdites lésions dont la claudication et l'ischémie chronique des membres. Les préparations pharmaceutiques comportent une dose à effet thérapeutique de FGF-2 et un excipient pharmacocompatible; les procédés de traitement des lésions des artères périphériques et de la claudication consistent à administrer à un patient au moins une dose unique d'un FGF, tel que le FGF-2, par voie intraartérielle, intraveineuse ou intramusculaire. Il est reconnu que des améliorations se produisent suite à l'administration de plusieurs doses, y compris de manière intermittente.
Borden Ladner Gervais Llp
Chiron Corporation
Novartis Vaccines And Diagnostics Inc.
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