C - Chemistry – Metallurgy – 07 – K
Patent
C - Chemistry, Metallurgy
07
K
C07K 14/315 (2006.01) A61K 38/16 (2006.01) A61K 39/39 (2006.01) A61K 39/395 (2006.01) A61P 35/00 (2006.01)
Patent
CA 2682521
The invention features peptides containing domain 4 of the Streptococcus intermedius intermedilysin (ILY) protein and fragments thereof, and the use of these peptides to sensitize cancer cells to antibody based anticancer treatments. CD59 receptor activity has been associated with a decreased sensitivity to therapeutic antibodies. Desriably, administration of ILY domain 4 polypeptides is sufficient to inhibit CD59 receptor activity while avoiding the general toxicity associated with full length ILY.
La présente invention concerne des peptides contenant le domaine 4 de la protéine intermedilysine (ILY) de Streptococcus intermedius et des fragments de celui-ci, et l'utilisation de ces peptides pour sensibiliser des cellules cancéreuses aux traitements anticancéreux à base d'anticorps. L'activité du récepteur CD59 a été associée à une sensibilité diminuée aux anticorps thérapeutiques. Idéalement, l'administration de polypeptides contenant le domaine 4 de l'ILY est suffisante pour inhiber l'activité du récepteur CD59 tout en évitant la toxicité générale associée à une ILY complète.
Hu Weiguo
Qin Xuebin
Goudreau Gage Dubuc
President And Fellows Of Harvard College
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