Methods and compositions for the treatment of psoriasis

A - Human Necessities – 61 – K

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Details

A61K 39/00 (2006.01) A61K 39/395 (2006.01) C07K 16/42 (2006.01) G01N 33/50 (2006.01) G01N 33/564 (2006.01) G01N 33/68 (2006.01)

Patent

CA 2310215

This invention provides methods of treating psoriasis which entail eliciting an immune response in an individual against an antigen aberrantly expressed in psoriatic tissue, such as a ganglioside, in an individual. The anti- ganglioside immune response is elicited by administration of an antigen such as a ganglioside, an anti-idiotype moiety for a ganglioside, or a polynucleotide encoding an anti-idiotype moiety. Also described is a strategy for developing additional compositions for psoriasis. The compositions elicit an immunological response against a target antigen present on psoriatic tissue, which in turn can be detected using antibody affinity-purified from the serum of the treated subject. The presence of the immunological response correlates positively with control or resolution of the psoriatic symptoms.

Cette invention concerne des procédés de traitement du psoriasis qui impliquent l'induction d'une réponse immunitaire, chez une personne, contre un antigène exprimé de manière anormale dans des tissus psoriasiques, tel qu'un ganglioside. La réponse immunitaire anti-ganglioside est induite par l'administration d'un antigène tel qu'un ganglioside, une fraction anti-idiotype destinée à un ganglioside ou un polynucléotide codant une fraction anti-idiotype. Cette invention concerne également une stratégie permettant de mettre au point d'autres compositions contre le psoriasis. Les compositions induisent une réponse immunitaire dirigée contre un antigène cible présent sur les tissus psoriasiques, qui, à son tour, peut être détectée à l'aide d'un anticorps purifié par affinité obtenu à partir du sérum du patient traité. La présence de la réponse immunitaire corrèle positivement le régulation ou la disparition des symptômes psoriasiques.

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