A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 31/455 (2006.01)
Patent
CA 2646729
Methods and compositions containing bicifadine are provided for the prevention and treatment of lower urinary tract disorders in mammalian subjects. The methods and compositions may be used to prevent or treat urinary incontinence, urinary urgency, nocturia, and enuresis associated with neurogenic and non-neurogenic overactive bladder, interstitial cystitis, prostatitis, prostadynia, and benign prostatic hyperplasia, among other conditions. Additional compositions and methods are provided which employ bicifadine in combination with a second anti-incontinence agent, or a different therapeutic agent to yield more effective anti- incontinence treatment tools, and/or dual activity therapeutic methods and formulations useful to prevent or reduce urinary incontinence and one or more additional symptoms such as urinary urgency, overflow, frequency, or pain in mammalian subjects.
L'invention concerne des méthodes et des compositions contenant de la bicifadine destinées à la prévention et au traitement de troubles des voies urinaires inférieures chez les mammifères. Les méthodes et des compositions de l'invention peuvent être utilisées pour prévenir ou traiter l'incontinence urinaire, la miction impérieuse, la polyurie nocturne, et l'énurésie associées à la vessie hyperactive neurogène ou non neurogène, à la cystite interstitielle, à la prostatite, à la prostadynie ou à l'hyperplasie prostatique bénigne, entre autres affections. L'invention concerne d'autres compositions et méthodes qui combinent la bicifadine à un second agent anti-incontinence ou à un agent thérapeutique différent pour fournir des outils de traitement anti-incontinence plus efficaces, et/ou des méthodes et formulations thérapeutiques à double action, utiles pour prévenir ou réduire l'incontinence urinaire et un ou plusieurs autres symptômes, tels que la miction impérieuse, la débâcle urinaire, la miction fréquente ou la douleur chez les mammifères.
Dov Pharmaceutical Inc.
Skolnick Phil
Smart & Biggar
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