A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 31/4375 (2006.01) A61K 31/138 (2006.01) A61K 31/444 (2006.01) A61K 31/713 (2006.01) A61P 9/00 (2006.01) A61P 9/04 (2006.01)
Patent
CA 2723372
The invention relates to methods of treating or preventing pathological cardiac remodeling and/or preventing heart failure. These methods include the administration of a PDE1 inhibitor to a patient under conditions effective to treat or prevent pathological cardiac remodeling, and therefore heart failure that occurs as a result of such remodeling. Pharmaceutical compositions and delivery vehicles that can be used in the methods of the present invention are also disclosed herein.
L'invention porte sur des procédés de traitement ou de prévention d'une remodélisation cardiaque pathologique et/ou de prévention d'une insuffisance cardiaque. Ces procédés comprennent l'administration d'un inhibiteur de PDEl à un patient dans des conditions efficaces pour traiter ou prévenir une remodélisation cardiaque pathologique, et en conséquence une insuffisance cardiaque qui se produit par suite d'une telle remodélisation. L'invention porte également sur des compositions pharmaceutiques et sur des véhicules d'administration qui peuvent être utilisés dans les procédés de la présente invention.
Li Jian-Dong
Yan Chen
Gowling Lafleur Henderson Llp
University Of Rochester
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