Methods and compositions for therapeutic treatment

Details Methods and compositions for therapeutic treatment Methods and compositions for therapeutic treatment

A - Human Necessities

61

K

A61K 31/436 (2006.01) A61K 31/352 (2006.01)

Patent

CA 2673863

Methods and compositions are described for the modulation of central nervous system and/or fetal effects of calcineurin inhibitors. Methods and compositions are described for the modulation of efflux transporter activity to increase the efflux of calcineurin inhibitors out of a physiological compartment and into an external environment. In particular, the methods and compositions disclosed herein provide for the increase of efflux transporter activity at Blood-Tissue, blood-CSF and placental-maternal barriers to increase the efflux of calcineurin inhibitor from physiological compartments, including central nervous system and fetal compartments.

La présente invention concerne des procédés et des compositions destinés à la modulation des effets des inhibiteurs de la calcineurine sur le système nerveux central et/ou sur le fAEtus. L'invention concerne également des procédés et des compositions destinés à la modulation de l'activité de transporteur d'efflux afin d'augmenter l'efflux d'inhibiteurs de la calcineurine sortant d'un compartiment physiologique et entrant dans un environnement externe. En particulier, les procédés et les compositions décrits ici permettent l'augmentation de l'activité de transporteur d'efflux aux barrières sang-tissu, hématoencéphalique et placenta-mère afin d'augmenter l'efflux d'inhibiteur de la calcineurine à partir de compartiments physiologiques, comprenant les compartiments du système nerveux central et du fAEtus.

Affiliated with

Also associated with

Rating

Methods and compositions for therapeutic treatment does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Methods and compositions for therapeutic treatment, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Methods and compositions for therapeutic treatment will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFCA-PAI-O-1452716