Methods and compositions for therapies using genes encoding...

Details Methods and compositions for therapies using genes encoding... Methods and compositions for therapies using genes encoding...

C - Chemistry, Metallurgy

12

N

C12N 15/86 (2006.01) A61K 48/00 (2006.01) C07K 14/565 (2006.01) C12N 5/10 (2006.01)

Patent

CA 2300480

Methods and pharmaceutical compositions for modifying cells of a mammalian recipient with DNA encoding a secreted protein such as human interferon in situ are provided. The methods include forming a secreted protein expression system in vivo or ex vivo and administering the expression system to the mammalian recipient. The expression system and methods are useful for the localized and systemic delivery of interferons in situ.

Cette invention se rapporte à des méthodes et à des compositions pharmaceutiques permettant de modifier des cellules d'un receveur mammalien au moyen d'ADN codant in situ une protéine sécrétée telle qu'un interféron humain. Ces méthodes consistent à former in vivo ou ex vivo un système d'expression de protéine sécrétée et à administrer ce système d'expression au receveur mammalien. Ce système d'expression et les méthodes associées s'avèrent utiles à l'administration in situ localisée et systémique d'interférons.

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