Methods and compositions for tissue regeneration

Details Methods and compositions for tissue regeneration Methods and compositions for tissue regeneration

A - Human Necessities

61

K

A61K 35/12 (2006.01) A61K 35/36 (2006.01) A61K 38/48 (2006.01) A61K 48/00 (2006.01) C12N 5/00 (2006.01)

Patent

CA 2497193

The present invention provides the use and composition of matter of angiogenic or other growth/cytokine factors expressed by mixtures of allogeneic human cell strains or lines of various types and stages of differentiation. Also provided are unencapsulated preparations (mixed with or applied to extracellular matrix material or synthetic biocompatible substances) for the purpose of temporary application to wounds or defects in the skin or other tissues for the restoration of blood supplying connective tissue to enable organ-specific cells to reestablish organ integrity as well as to inhibit excessive scar formation.

L'invention concerne une composition de matière dans laquelle des facteurs angiogéniques ou d'autres facteurs de croissance/cytokine sont exprimés par des mélanges de souches ou lignées cellulaires allogéniques humaines à types et phases de différenciation divers, et l'utilisation de cette composition. L'invention concerne également des préparations non encapsulées (mélangées avec ou appliquées à un matériau de matrice extracellulaire ou à des substances synthétiques biocompatibles), pour les besoins d'une application temporaire sur des blessures ou des défectuosités de la peau ou sur d'autres tissus, visant à régénérer le tissu connectif d'irrigation sanguine et à permettre ainsi à des cellules spécifiques aux organes de rétablir l'intégrité des organes et d'inhiber une formation cicatricielle excessive.

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