Methods and compositions for tissue regeneration

A - Human Necessities – 61 – L

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A61L 27/36 (2006.01) A61L 27/24 (2006.01)

Patent

CA 2684011

A decellularised collagen-containing matrix for guided tissue regeneration, wherein the matrix is derived from a natural tissue material and is substantially free of non-fibrous tissue proteins, cellular elements and lipids or lipid residues and wherein the matrix displays the original collagen fibre architecture and molecular ultrastructure of the natural tissue material from which it is derived. The decellularised collagen-containing matrix is useful as an implant for guided tissue regeneration, having a capacity to induce guided regeneration of host tissue.

L'invention concerne une matrice décellularisée contenant du collagène pour la régénération tissulaire guidée, ladite matrice étant dérivée d'un matériau tissulaire naturel et étant sensiblement exempte de protéines tissulaires non fibreuses, d'éléments cellulaires et de lipides ou de résidus lipidiques. La matrice de l'invention présente l'architecture de fibre de collagène originale et l'ultrastructure moléculaire du matériau tissulaire naturel à partir duquel elle est dérivée. Ladite matrice décellularisée contenant du collagène est utile en tant qu'implant pour la régénération tissulaire guidée et présente une certaine capacité pour induire une régénération guidée de tissus hôtes.

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