C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
C12N 5/10 (2006.01) A61K 35/14 (2006.01) A61K 39/385 (2006.01) A61K 49/00 (2006.01) C12N 5/06 (2006.01) C12N 15/86 (2006.01) C12Q 1/02 (2006.01) G01N 33/554 (2006.01) A61K 38/00 (2006.01) A61K 48/00 (2006.01)
Patent
CA 2245170
Recombinant dendritic cells are made by transforming a stem cell and differentiating the stem cell into a dendritic cell. The resulting dendritic cell is an antigen presenting cell which activates T cells against MHC class I- antigen targets. Kits, assays and therapeutics are based upon the activation of T cells by the recombinant dendritic cell. Cancer, viral infections and parasitic infections are all ameliorated by the recombinant dendritic cells, or corresponding activated T cells. Therapeutic compositions and pharmaceutical compositions are provided.
Des cellules dendritiques de recombinaison sont réalisées en transformant une cellule souche et en différenciant la cellule souche en une cellule dendritique. La cellule dendritique obtenue est une cellule présentant l'antigène qui active les lymphocytes T contre des cibles d'antigènes de classe I de complexe majeur d'histocompatibilité. L'invention concerne également des kits, des dosages et des procédés thérapeutiques fondés sur l'activation des lymphocytes T par la cellule dendritique de recombinaison. Les cancers, les infections virales et parasitiques sont améliorés par les cellules dendritiques de recombinaison ou les lymphocytes T activés correspondants. L'invention traite également de compositions thérapeutiques et pharmaceutiques.
Hwu Patrick
Reeves Mark
Rosenberg Steven A.
Department Of Health And Human Services The Government Of The United States Of America Represented By Th
Fetherstonhaugh & Co.
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